药品信息:
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部分中文Indobufene Ranb处方资料（仅供参考）
【药理与适用症】: 吲哚布芬可抑制引起血小板激活的一些因子(如ADP、5-HT、血小板因子4、β—小板球蛋白等)的释放以及影响花生四烯酸代谢而抗血小板聚集，但不影响PGI2的血浓度。对血液凝固的各种参数无影响，但能中等度地延长出血时间，停药后即可恢复。
口服后吸收迅速，血浆浓度达峰时间2小时；t1/2为8小时；与血浆蛋白结合率为99％。
用于动脉硬化所致的缺血性心、脑血管和周围血管疾病、静脉血栓形成、血酯代谢障碍等；也可用于体外循环手术时防止血栓形成。
【注意事项】: 偶有上腹不适、腹胀、胃肠道出血和鼻衄。有时出现过敏反应(荨麻疹)。禁用于有出血性疾病、妊娠及哺乳妇。
【用法与用量】: 每日剂量200—400mg，分2次口服或肌注或静注。老人及肾功能不全者宜减半。
【包装】: 片剂：每片200mg。注射液：每支200mg(2ml)。
NAME INDOBUFENE RAN * 200mg 30cpr
COMPANY Ranbaxy Italy S.p.A.
CLASS C
RECIPE RR - a medicinal product subject to medical prescription
ATC B01AC10
Indobufene
ACTIVE indobufene ( DC.IT )
GROUP Therap. antiplatelet
TYPE Indobufene
VALIDITY ' 30 months
THERAPEUTIC INDICATIONS
antiplatelet treatment in pathological conditions where hyperactivity or platelet activation may play a key role in the pathogenesis of thrombosis , such as : ischemic heart and cerebral vascular disease , atherosclerotic peripheral arterial disease , venous thrombosis , dyslipidemia and diabetes. Prevention of activation of thrombogenesis during extracorporeal circulation (hemodialysis )
DOSAGE AND ADMINISTRATION
the daily dosage is generally between 200 and 400 mg orally in 2 doses . The lower dose ( 200 mg / day ) is particularly suitable for long-term treatments . In the treatment of elderly patients, dosage should be carefully determined by the physician must evaluate a possible reduction of the dosages indicated above. In patients older than 65 years , the recommended dose is between 100 and 200 mg / day. E ' recommended taking the drug after meals. In the prevention of thrombogenesis during extracorporeal circulation (hemodialysis ) indobufene dose depends on the condition of the patient to the physician's judgment may be given 100 mg orally before each dialysis session . Renal impairment : In subjects with renal impairment is appropriate dose reductions in relation to the degree of renal function. As an indication, we suggest the following scheme: CrCl > 80 ml / min: 100-200 mg 2 times a day CrCl = 40-80 ml / min: 100 mg / day - 100 mg 2 times a day, creatinine clearance <40 ml / min: 100 mg every other day - 100 mg / day |
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