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  药店国别: 意大利药房
产地国家: 意大利
所属类别: 抗微生物药物->抗炎
处方药:处方药
包装规格: 600毫克/片 30片/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
赞邦制药
生产厂家英文名:
ZAMBON ITALIA Srl
该药品相关信息网址1:
http://drugs-about.com/drugs-s/spidifen.html
原产地英文商品名:
SPIDIFEN 600mg/tab 30tabs/box
原产地英文药品名:
ARGININE AND IBUPROFEN
中文参考商品译名:
SPIDIFEN 600毫克/片 30片/盒
中文参考药品译名:
精氨洛芬
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Anti-rheumatic
英文适应病症2:
Mild to moderate pain
英文适应病症3:
Fever
英文适应病症4:
Anti-inflammatory
临床试验期:
完成
中文适应病症参考翻译1:
抗风湿
中文适应病症参考翻译2:
轻、中度疼痛
中文适应病症参考翻译3:
发热
中文适应病症参考翻译4:
抗炎
药品信息:

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 详细处方信息以本药内容附件PDF文件(2011113023192618.PDF,2011113023191928.PDF,2011113023191419.PDF)的“原文Priscribing Information”为准
---------------------------------------------------------------
部分中文精氨洛芬处方资料(仅供参考)

【药品名称】精氨洛芬

【英文名称】Arginine and Ibuprofen

【其他名称】精氨洛芬颗粒, 精氨酸布洛芬颗粒, 快速平, 司百得, 儿快平, 快平

【功能与主治】
1.口服或局部给药用于缓解类风湿关节炎、骨性关节炎、脊柱关节病、痛风性关节炎、风湿性关节炎等各种慢性关节炎的急性发作期或持续性的关节肿痛症状。
2.口服或局部给药用于非关节性的各种软组织风湿性疼痛或炎症,如肌腱及腱鞘炎、滑囊炎、肩痛、肌痛及运动后损伤性疼痛等。
3.口服给药用于急性轻、中度疼痛,如手术、创伤、劳损后疼痛、原发性痛经、继发性痛经(放置宫内节育器引起)、下腰疼痛、牙痛、头痛等。
4.口服或直肠给药可用于感冒、急性上呼吸道感染、急性咽喉炎等疾病引起的发热。

【注意事项】
1.交叉过敏对阿司匹林或其它非甾体类抗炎药过敏者,也可能对本药过敏。
2.禁忌症
(1)对本药过敏者。
(2)对阿司匹林或其它非甾体类抗炎药过敏者。
(3)活动性消化性溃疡或溃疡合并出血(或穿孔)者。
(4)有失血倾向者。
(5)孕妇。
(6)哺乳期妇女。
(7)脱水小儿禁用本药滴剂。
(8)对丙二醇及对羟基苯甲酸甲酯钠过敏者禁用本药乳膏。
3.慎用
(1)支气管哮喘患者或有此病史者(可能引起支气管痉挛)。
(2)心功能不全、高血压患者。
(3)血友病或其它出血性疾病(包括凝血障碍及血小板功能异常)患者。
(4)有消化性溃疡史者。
(5)肠胃疾病患者。
(6)严重肝功能不全者。
(7)肾功能不全者。
(8)红斑狼疮或其它免疫疾病患者。
(9)6个月以下小儿。
4.药物对妊娠的影响妊娠晚期用药可使孕期延长,引起难产及产程延长。美国药品和食品管理局(FDA)对本药的妊娠安全性分级为B级,妊娠晚期为D级。
5.药物对检验值或诊断的影响
(1)可抑制血小板聚集,使出血时间延长(停药24小时后该作用即可消失)。
(2)血尿素氮及血清肌酸酐含量升高,肌酐清除率下降。
(3)氨基转移酶升高。
6.用药前后及用药时应当检查或监测用药期间应定期检查血常规及肝、肾功能。

【不良反应】
1.消化系统可出现消化不良(约16%),也较多见胃烧灼感、胃痛、恶心、呕吐等,但症状较轻,停药后即消失,不停药也可耐受。偶见消化性溃疡和消化道出血(发生率均低于1%),亦有因溃疡而致穿孔的报道。
2.神经系统偶可出现头痛、嗜睡、晕眩、耳鸣等,发生率约为1%-3%。抑郁或其它精神症状、视物模糊及中毒性弱视少见。
3.肝脏肝毒性反应轻微,可见肝功能异常,主要表现为氨基转移酶升高。
4.肾脏少数患者用药后可出现下肢浮肿。对一些有潜在性肾病的易感者可出现肾乳头坏死的急性肾功能不全。
5.血液系统大剂量用药可出现出血时间延长、白细胞减少、粒细胞减少甚至粒细胞缺乏、血小板缺乏及全血细胞减少。个别病例可因胃肠道隐血而致贫血。
6.皮肤过敏性皮肤反应不常见,多为短暂性荨麻疹、紫癜性或红斑性改变,常伴有瘙痒。
7.呼吸系统易感者可出现支气管哮喘发作。

【用法与用量】
成人
·常规剂量
·口服给药
1.抗风湿:一次0.4-0.8g,一日3-4次。类风湿关节炎比骨性关节炎用量大。一日最大用药量不超过2.4g。
2.轻、中度疼痛:
(1)一次0.2-0.4g,每4-6小时1次。一日最大用药量不宜超过2.4g。
(2)分散片:推荐剂量为一次0.2-0.4g,一日3次。
(3)缓释片:一次0.3-0.6g,早、晚各一次。
(4)缓释胶囊:一次0.3g,早、晚各一次。
(5)缓释混悬剂:推荐剂量为一次0.3-0.6g,一日2次。
3.发热:(1)一次0.2g,一日3-4次。
(2)分散片:推荐剂量为一次0.2-0.4g,一日3次。
(3)缓释混悬剂:推荐剂量为一次0.3-0.6g,一日2次。
4.抗炎:
(1)缓释片:一次0.3-0.6g,早、晚各一次。
(2)缓释胶囊:一次0.3g,早、晚各一次。
(3)缓释混悬剂:推荐剂量为一次0.3-0.6g,一日2次。
·局部给药乳膏:依患处面积大小,取适量轻揉患处,一日3-4次。搽剂:涂患处,一次2-4ml,一日3次。
·直肠给药一次100mg,如需再次用药应间隔4小时以上。
儿童
·常规剂量
·口服给药12岁以上儿童用法用量同成人(除风湿性疾病)。1-12岁儿童用法用量如下:
1.发热:
(1)分散片、混悬液:推荐剂量为一日20mg/kg,分3次服用。
(2)缓释混悬剂:推荐剂量为一日20mg/kg,分2次服用。
(3)混悬滴剂具体用法如下:一次5-10mg/kg,需要时每6-8小时重复使用,每24小时不超过4次。或参照下表,用滴管量取。使用前请摇匀使用后请清洗滴管。
年龄、体重剂量表
年龄体重(kg)剂量(次)
6-11月5.5-8.01滴管(1.25ml)
12-23月8.1-12.01.5滴管(1.875ml)
2-3岁12.1-15.92滴管(2.5ml)
2.疼痛:(1)分散片、混悬液:推荐剂量为一日30mg/kg,分3次服用。(2)缓释混悬剂:推荐剂量为一日30mg/kg,分2次服用。(3)混悬滴剂用法用量同发热项。
3.风湿性疾病:用于12岁以上儿童,混悬液推荐剂量为一次0.3-0.4g,一日3-4次。
·局部给药参见成人用法与用量。
·直肠给药1-3岁患儿:一次50mg,塞肛门内。如症状无缓解,每4-6小时可重复给药1次,24小时不超过200mg。3岁以上患儿:一次100mg。

【禁忌】
(1)对本药过敏者。
(2)对阿司匹林或其它非甾体类抗炎药过敏者。
(3)活动性消化性溃疡或溃疡合并出血(或穿孔)者。
(4)有失血倾向者。
(5)孕妇。
(6)哺乳期妇女。
(7)脱水小儿禁用本药滴剂。
(8)对丙二醇及对羟基苯甲酸甲酯钠过敏者禁用本药乳膏。

Product trade name: Spidifen

Pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products:
Ibuprofen Arginine

Spidifen available forms, composition, doses:
N / A

Spidifen destination | category:
Human:
Other Nonsteroidal Antiimflammatory Agents

Indications and usages, anatomical therapeutic chemical and diseases classification codes:
M01AE01 - Ibuprofen

Pharmaceutical companies, researchers, developers, manufacturers, distributors and suppliers:
Zambon

There is an additional general information about this medication active ingredient ibuprofen:

Pharmacological action
NSAIDs, a derivative of phenylpropionic acid, ibuprofen has anti-inflammatory, analgesic and antipyretic effect.
The mechanism of action is associated with inhibition of COX activity - the main enzyme metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever. Analgesic effect is due to both peripheral (indirectly, through suppression of prostaglandin synthesis), and a central mechanism (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system). Inhibits platelet aggregation.
For topical use anti-inflammatory and analgesic action. Reduces morning stiffness, increased the amount of motion in joints.

Pharmacokinetics
When oral administered ibuprofen almost completely absorbed from the gastrointestinal tract. Simultaneous food intake slows the rate of absorption. Metabolised in the liver (90%). T1 / 2 is 2-3 hours.
80% of the dose excreted in urine mainly as metabolites (70%), 10% - unchanged, 20% eliminated through the intestine in the form of metabolites.

Why is Spidifen prescribed?
Inflammatory, degenerative diseases of joints and spine (including rheumatic and rheumatoid arthritis, ankylosing spondylitis, osteoarthritis), articular syndrome in patients with acute gout, psoriatic arthritis, ankylosing spondylitis, tendonitis, bursitis, sciatica, traumatic inflammation of soft tissue and musculoskeletal apparatus. Neuralgia, myalgia, pain in infectious and inflammatory diseases of ENT organs, bursitis, algomenorrhea, headache and toothache. Fever in infectious and inflammatory diseases.

Dosage and administration
Setting individually, depending on etiology of disease, severity of clinical manifestations. When administered rectally or adult single dose of 200-800 mg, the frequency of reception - 3-4; for children - 20-40 mg / kg in divided doses.
Topical applied within 2-3 weeks.
The maximum daily dose for adults when administered oral or rectally or is 2.4 g.
Oral, after a meal. Rheumatoid arthritis - by 0.8 g 3 times a day in osteoarthrosis and ankylosing spondylitis - by 0.4-0.6 g 3-4 times a day, in juvenile rheumatoid arthritis - at 30-40 mg / kg / day in several stages.
When soft tissue injuries, sprains - 1.6-2.4 g / day in divided doses.
At moderate pain syndrome - 1.2 g per day.

Spidifen side effects
Digestive system: frequently - nausea, anorexia, vomiting, epigastric discomfort, diarrhea, possibly the development of erosive and ulcerative lesions of the gastrointestinal tract; rare - bleeding from the gastrointestinal tract, long-term use possible liver problems.
Central nervous system and peripheral nervous systems: frequently - headache, dizziness, sleep disturbances, agitation, visual impairment.
Hemopoietic system: long-term use may be anemia, thrombocytopenia, agranulocytosis.
Urinary tract: long-term use possible renal dysfunction.
Allergic reactions: often - skin rash, Quincke's edema, rarely - aseptic meningitis (usually in patients with autoimmune diseases), bronchospasm syndrome.
Local reactions: when topical used may be hyperemia of the skin, burning or tingling.

Contraindications
Erosive-ulcerative lesions in the gastrointestinal tract exacerbation, diseases of the optic nerve, "aspirin triad", hemodyscrasia, pronounced renal dysfunction and / or liver, children age (to 6 years), hypersensitivity to ibuprofen.

Using during pregnancy and breastfeeding
Do not use ibuprofen in the III trimester of pregnancy. Application I and II trimesters of pregnancy is justified only in cases where the expected benefit to the mother than the possible harm to the fetus.
This medication ibuprofen in small amounts excreted in breast milk. Possible using in lactation for pain and fever. If necessary, prolonged use or use in high doses (800 mg / 24 h), should decide on the termination of breastfeeding.

Special instructions
Precautions are used with the attendant liver and kidney diseases, chronic heart failure, with dyspeptic symptoms before treatment, immediately after surgery, with indications of a history of gastrointestinal bleeding in diseases of the digestive tract, allergic reactions associated with NSAID intake.
In the course of treatment requires systematic monitoring of the liver and kidneys, peripheral blood picture.
It should not be applied externally to the damaged skin.

Spidifen drug interactions
With simultaneous use of ibuprofen reduces the effect of antihypertensive agents (ACE inhibitors, beta-blockers), diuretics (furosemide, hypothiazide).
With the simultaneous use of anticoagulants may enhance their action.
With simultaneous application of SCS increases the risk of side effects from the gastrointestinal tract.
With the simultaneous application of ibuprofen may displace from compounds with plasma proteins indirect anticoagulants (acenocoumarol), derivatives of hydantoin (phenytoin), oral hypoglycemic drugs sulfonylurea derivatives.
With the simultaneous use of amlodipine may be a slight reduction of antihypertensive action of amlodipine, with acetylsalicylic acid - decreased concentration of ibuprofen in blood plasma, with baclofen - described a case of toxic gain of baclofen.
When applied simultaneously with warfarin may increase bleeding time, were also observed microhematuria, bruises with hydrochlorothiazide - perhaps a slight reduction of antihypertensive action of hydrochlorothiazide, captopril - may reduce antihypertensive effect of captopril, with cholestyramine - moderately decrease absorption of ibuprofen.
With simultaneous application of lithium carbonate increased the concentration of lithium in blood plasma.
With simultaneous application of magnesium hydroxide increases the initial absorption of ibuprofen, with methotrexate - increases the toxicity of methotrexate.

Spidifen in case of emergency / overdose
In case of overdose, call your local poison control center or emergency services.
Symptoms of overdose may include: dizziness; fast eye movements that you cannot control; slow breathing or short periods of time without breathing; blue color around the lips, mouth, and nose.

Storage conditions
In a dry, protected from light place, at temperatures below 25°C. Expiration date for ibuprofen: 3 years.

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 详细处方信息以本药内容附件PDF文件(2011113023192618.PDF,2011113023191928.PDF,2011113023191419.PDF)的“原文Priscribing Information”为准
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更新日期: 2013-08-06
附件:


2011113023192618.PDF    

2011113023191928.PDF    

2011113023191419.PDF    

 
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