药品信息:
--------------------------------------------------------------- 详细处方信息以本药内容附件PDF文件(201251723122721.PDF)的“原文Priscribing Information”为准 --------------------------------------------------------------- 部分中文丙磺舒处方资料(仅供参考)
中文名称: 丙磺舒
CAS号: 57-66-9
中文同义词: 对-(二丙基氨磺酸)苯甲酸;羧苯磺胺;丙磺舒;对[(二丙氨基)磺酰基]苯甲酸;对照品;4-(二丙基氨磺酰基)苯甲酸;丙苯尼西德;羧苯磺丙胺
英文名称: Probenecid
英文同义词: 4-((dipropylamino)sulfonyl)-benzoicaci;4-(Dipropylsulfamoyl)benzoic acid;4-(dipropylsulfamoyl)benzoicacid;4-[(dipropylamino)sulfonyl]-benzoicaci;Apurina;benacen;Benemid;benemide
药物剂型: 片剂:0.25g,0.5g。 药理作用: 本品为肾小管阻断药物,抑制肾小管对尿酸盐的再吸收,促进尿酸的排泄,使尿酸血浆浓度降低,减少尿酸的沉积,促进尿酸沉积物的再吸收,从而发挥抗慢性痛风的作用。 药动学: 口服给药在胃内吸收迅速,完全。蛋白结合率达85%~90%,成人1次口服给药1g,2~4小时血药浓度达高峰值30µg/ml,1次口服2g,4小时血药浓度高峰值150~200µg/ml。半衰期为6~12h,代谢物主要经肾排出,有5%~10%以原型药物排出。 适应证: 本品用于痛风性关节炎和高尿酸血症痛风的长期治疗,不用于急性痛风。可作为抗生素的辅助用药,以提高青霉素、成半合成青霉素及头孢菌素类的药理活性,因本品能使这些抗生素血药浓度时间延长。 禁忌证: 本品属磺胺药物,注意有交叉过敏反应的患者禁用,孕妇、消化性溃疡、肾功能障碍患者应慎用本品。 注意事项: 给药期间注意血象变化,应大量饮水和服用适量苏打。本品可提高抗生素血药浓度,但可能毒性增加,本品不可与氨甲蝶呤配伍,与氯噻酮、利尿酸、速尿、吡嗪酰胺及噻嗪类药物同时给药,要注意调整剂量,以防高尿酸血症。 不良反应: 有恶心、呕吐、食欲减退和头痛,还可出现尿酸结石、尿频、面部潮红、牙龈疼痛、呼吸困难、皮肤瘙痒,发热、皮疹、过敏反应等。极个别患者有出血、粒细胞减少、再生性障碍性贫血、肾病综合征、肝坏死等。 用法用量: 治疗慢性痛风,成人口服给药初始1次量250mg,2次/d,共1周,以后1次给药500mg,2次/d;用于抑制抗生素排泄,1次给药500mg,4次/d;用于2岁以上小儿抑制抗生素排泄,每公斤体重初始1次给药25mg,以后每公斤体重10mg,4次/d。 药物相应作用: 丙磺舒能抑制青霉素类药物和对氨水杨酸的排泄,从而延长这些药物在机体组织中的药理活性,加强其疗效和毒性。不宜与水杨酸、依他尼酸、氢氯噻嗪、醋唑酰胺、保泰松、吲哚美辛及口服降糖药等同服。与磺胺有交叉过敏反应。 专家点评: 1.本品无抗炎、镇痛作用,对痛风急性发作无效。2.服药时应大量饮水,并加用碳酸氢钠以碱化尿液。
GENERIC NAME: probenecid
BRAND NAME: Benemid (brand is no longer available)
DRUG CLASS AND MECHANISM: Probenecid is an oral drug used for reducing blood uric acid levels in patients with hyperuricemia (high uric acid) and/or. High uric acid can cause attacks of gout and kidney stones. Probenecid prevents attacks of gout by reducing uric acid levels in the blood. It does this by preventing the reabsorption of uric acid by the kidney and increasing its excretion from the body in the urine. Probenecid also blocks excretion by the kidney of penicillin and related antibiotics and is used for increasing the levels of the antibiotics in the blood and increasing their effectiveness when treating infections.
PRESCRIPTION: Yes
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 0.5 g
STORAGE: Probenecid should be stored at room temperature, 15-30 C (59-86 F).
PRESCRIBED FOR: Probenecid is used for the treatment of hyperuricemia associated with gout. It also is used for increasing blood levels of penicillin-type antibiotics (for example, ampicillin and amoxicillin) when treating gonorrhea.
DOSING: The usual adult dose for hyperuricemia is 500 mg twice daily and the maximum dose is 2 grams daily. When combined with penicillin type antibiotics to treat infections, the usual dose is 500 mg 4 times daily. Patients should drink plenty of water in order to prevent formation of kidney stones and take probenecid with food or antacid to reduce stomach upset.
DRUG INTERACTIONS: Probenecid blocks excretion of some drugs by the kidney and, therefore, may increase blood levels and side effects of methotrexate (Rheumatrex, Trexall) and nonsteroidal antiinflammatory drugs (NSAIDs), for example, ibuprofen (Advil), naproxen (Aleve), indomethacin (Indocin), ketorolac (Toradol) and others. Aspirin may reduce the action of probenecid through unknown mechanisms.
PREGNANCY: Probenecid has not been adequately studied in pregnant women.
NURSING MOTHERS: Probenecid has not been adequately studied in nursing mothers.
SIDE EFFECTS: Common side effects of probenecid include headache, dizziness, nausea, vomiting, skin rash, sore gums, and fever. Probenecid may cause a flare of gout and kidney stones, and it is not started during an acute attack of gout. Serious but rare side effects include reduced red blood cell counts (anemia), liver damage and severe allergic reactions.
--------------------------------------------------------------- 详细处方信息以本药内容附件PDF文件(201251723122721.PDF)的“原文Priscribing Information”为准 --------------------------------------------------------------- |