您好,欢迎光临世界标品! 登录 注册(订药物标准品请用邮件联系我们)

SCITEK INTERNATIONAL (H.K.) LIMITED
Email: sciteck.hongkong@gmail.com
 

当前本网站药物产品种数共 8524 处方药 8148 非处方药 269 保健品/医疗用具 107

世界标品医药目录搜索(中英文):
世界各国官方药品目录搜索(英文):
世界标品医药知识搜索(中英文):

联系方式
国内客服电话:
国际免费电话:

咨询邮箱:
scimed.shanghai@shijiebiaopin.com
info@shijiebiaopin.com
pharmacy.shijiebiaopin1@gmail.com
pharmacy.shijiebiaopin2@gmail.com

  药店国别: 英国药房
产地国家: 英国
所属类别: 心血管系统药物->降血脂药物
处方药:处方药
包装规格: 160毫克/片 28片/盒
计价单位:
   
生产厂家中文参考译名:
福尼埃公司
生产厂家英文名:
Laboratories Fournier
该药品相关信息网址1:
http://www.drugs.com/uk/supralip-160mg-spc-2401.html
该药品相关信息网址2:
http://www.netdoctor.co.uk/heart-and-blood/medicines/supralip.html
该药品相关信息网址3:
http://www.medicines.org.uk/emc/medicine/3719/SPC/Supralip+160mg/
原产地英文商品名:
SUPRALIP((Equivalent LIPANTHYL)) 160MG/TAB 28TABS/BOX
原产地英文药品名:
FENOFIBRATE
中文参考商品译名:
SUPRALIP(等效于力平之) 160毫克/片 28片/盒
中文参考药品译名:
非诺贝特
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Fat metabolism barriers to hyperlipidemia
英文适应病症2:
Hyperlipidemia
临床试验期:
完成
中文适应病症参考翻译1:
脂肪代谢障碍血症
中文适应病症参考翻译2:
高脂血症
药品信息:

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件(201232922531324.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------
部分中文非诺贝特处方资料(仅供参考)

福尼埃公司在英国上市非诺贝特新制剂
    福尼埃制药公司在英国上市了非诺贝特(Fenofibrate)超级生物利用度(Supra-bioavailable)新制剂,商品名为SupraliP,用于治疗脂肪代谢障碍血症。其费用较该公司目前微分化药物制剂(LiPantil 200mg)约少30%,可望取代现有产品。经欧联盟共同认可的程序批准后上市。此新制剂已在德国销售,可望在签订价格协议后进一步在欧联盟国家里上市。它也已在加拿大销售,商品名为Li-Pidil SuPra。SuPraliP将得益于DAIS(糖尿病动脉粥样硬化介人研究),结果显示非诺贝特使Ⅱ型糖尿病动脉粥样硬化加重的减少高达40%

非诺贝特Fenofibrate 
中文别名:
非诺贝特、苯酰降脂丙酯、立平脂、普鲁脂、普鲁脂芬

英文别名:Fenobrate、Lipantil、Lipidax、Lipidex、Lipifen、Lipoclar、Procetofeme、Procetoken、Tilene
 
药品类别:调节血脂药 
 
药理药动 
药效学
降低血甘油三酯,其可能机制为:①抑制新的游离脂酸的合成,促进线粒体中游离脂酸的氧化,抑制极低密度脂蛋白的合成与分泌,抑制甘油三酯合成;②增强脂蛋白脂酶的活性,使载脂蛋白C11与C111的比率增高而有助于脂蛋白脂酶的作用,使甘油三酯分解。降低血胆固醇, 其可能机制为: ①抑制β羟基β甲戊二酸单酰辅酶A还原酶的活性而减少胆固醇合成;②刺激低密度脂蛋白受体的产生而加速胆固醇代谢。本品尚有降低高尿酸血症的血尿酸作用, 和增高血高密度脂蛋白的作用。药动学
口服后, 尤其餐后, 吸收快。口服后4~7小时左右血药浓度达峰值.单剂口服后半衰期α与半衰期β分别为4.9小时与26.6小时,表观分布容积为0.9L/kg; 持续治疗后半衰期β为21.7小时。吸收后在肝、肾、肠道中分布多,其次为肺、心和肾上腺,睾丸、脾、皮肤内有少量。在肝内与肾组织内代谢,经羧基还原与葡糖醛酸化,代谢产物以葡糖醛酸化产物占大多数,经肾排出。
[药理作用]是第三代纤维酸类降脂药,具有作用较好,毒副作用较小等特点。主要作用为:①竞争性抑制胆固醇合成酶系中限速酶甲基羟戊二酰辅酶A还原酶,使胆固醇合成减少。②增加低密度脂蛋白受体数目,使肝细胞清除低密度脂蛋白增加。③增加脂蛋白酯酶活性,使极低密度脂蛋白清除增加。④尚有降低血液粘度、抗凝、改善微循环等作用。
药动学
口服吸收良好,达峰时间为4~6h。口服300mg后峰浓度为6.1±2.3μg/ml,半减期为26±2.9h,吸收后在体内通过组织脂酶迅速水解为非诺贝特酸。该酸与血浆蛋白结合牢固。大部分以结合物形式经尿排泄,尿中原形约占10%,经胆汁排泄的量不到20%。患者肾功能正常者长期服用无蓄积现象。

适 应 症 
用于治疗Ⅱ、Ⅲ、Ⅳ型高脂蛋白血症。
对正常人、非遗传性和遗传性高脂血症患者都有降脂作用。对胆固醇、甘油三酯、极低密度脂蛋白胆固醇、载脂蛋白B均有降低作用,对高密度脂蛋白胆固醇、载脂蛋白A-1均有升高作用,可作为第一线降脂药,也可作为其他降脂药物治疗失败后的替代药物。疗程越长,原来血脂水平越高者则降脂效果越好。

用法用量 
成人常用量口服,一次 0.1g,每日 3次,维持量每次 0.1g,每日 1—2次。
[制剂与规格]非诺贝特片0.1g
非诺贝特胶囊0.1g
口服,一次0.1-0.2g,一日2次.
[用法及用量]口服,每次0.1g,每日3次。
对血脂轻度增高者,可先用作用轻、副作用小的药物治疗。如疗效不佳再考虑使用本药。
用前先查肝功能,然后每2周复查1次,如转氨酶升高应停药。
血脂下降至正常后,再使用2~4周左右停药。
[剂型与规格]片剂:100mg/片。
[商品名]立平脂,Lipanthyl。
 
不良反应 
约有 2—15%。胃肠道反应包括腹部不适、腹泻、便秘最常见(约 5%);神经反应包括乏力、头痛、性欲丧失、阳萎、眩晕、失眠(约 3—4%);肌痛伴血肌酸磷酸激酶增高(约1%);皮疹(2%)。有胆石增加趋向。
偶有血转氨酶增高,包括丙氨酸氨基转移酶和门冬氨酸氨基转移酶。
个别病例可有肝功能障碍.
长期治疗时可有口干、胃肠部不适、食欲不振、腹泻、便秘、腹胀、肌痛、头痛、失眠、头晕、疲乏、皮疹、转氨酶和肌酸磷酸激酶升高、血浆尿素、肌酐升高,偶可见蛋白尿、白细胞减少、体重减轻,一般不影响继续治疗。
它比氯贝特易产生胆囊结石,因为它有较大的合成胆固醇作用。

禁忌症 
(1)孕妇与乳母禁用。
(2)老年人如有肾功能不良,须适当减少本品剂量。
(3)下列情况慎用:胆石症、肝功能不全、肾功能不全。

药物相互作用 
有增强抗凝作用,同时应用的口服抗凝药用量应减半,以后按检查结果调整用量。
①可与考来替泊合用以增高疗效,特别对升高高密度脂蛋白有作用。②本品能增强抗凝剂作用,故应将抗凝剂剂量减少,然后再根据情况进行调整。

Supralip (fenofibrate)
How does it work?
Supralip tablets contain the active ingredient fenofibrate, which is a type of medicine called a fibrate. (NB. Fenofibrate is also available without a brand name, ie as the generic medicine.) Fenofibrate is used to lower the levels of fats (lipids) called cholesterol and triglycerides in the blood.

For the sake of simplicity, there are two sorts of cholesterol; a 'bad' sort called low density lipoprotein (LDL) and a 'good' sort called high density lipoprotein (HDL). LDL is deposited in the arteries and increases the risk of heart disease by clogging and narrowing the arteries (atherosclerosis), while HDL actually protects the arteries against this.

Triglycerides are another type of 'bad fat' that increase the risk of hardened arteries.

Fenofibrate works mainly by stimulating the action of an enzyme that breaks down triglycerides and LDL cholesterol. This is called lipoprotein lipase and is found in muscle and fat tissue. Stimulating this enzyme increases the breakdown of triglycerides and LDL in the blood.

Fenofibrate also increases levels of HDL cholesterol. The overall effect is lowered levels of "bad fats" and raised levels of "good fats" in the blood.

Fibrates have an important role in the prevention of coronary heart disease. They reduce the risk of excess cholesterol and triglycerides being deposited in the major blood vessels of the heart (atherosclerosis). Atherosclerosis limits the amount of blood and therefore oxygen being carried to the heart muscle. This can cause chest pain (angina) and in severe cases can result in a heart attack (myocardial infarction).

This medicine is used when blood lipid levels cannot be lowered by diet and exercise alone. It is important to continue to follow a cholesterol-lowering diet and exercise regime while taking fenofibrate. Discuss this with your doctor.

What is it used for?
High levels of fats (lipids) such as cholesterol and triglycerides in the blood (hyperlipidaemia).

Warning!
You should should continue to follow a cholesterol-lowering diet during treatment with this medicine. Discuss this with your doctor.
This medicine may very rarely have side effects on the muscles. For this reason you should inform your doctor immediately if you experience any muscular symptoms such as pain, tenderness, cramps, or weakness while taking this medicine, particularly if it is accompanied by a fever or feeling generally unwell. Your doctor may need to check for side effects on the muscles by taking a blood test to measure the level of a compound called creatinine kinase in your blood. If this is the case, the test should not be done following strenuous exercise.
You should have regular blood tests to monitor your liver function (liver function tests) while taking this medicine. These should be every three months for the first 12 months of treatment. Symptoms that may suggest a problem with your liver include unexplained itching, yellowing of the skin or whites of the eyes (jaundice), unusually dark urine or pale stools, nausea and vomiting and abdominal pains. Tell your doctor if you experience any of these symptoms while taking this medicine.
Supralip tablets should be stored in their original package and not transferred to other containers in order to protect them from moisture.

Use with caution in
Elderly people.
Underactive thyroid gland (hypothyroidism).
History of muscle disease.
Low levels of the protein albumin in the blood (hypoalbuminaemia).
People who drink large amounts of alcohol.

Not to be used in
Children.
Decreased kidney function.
Decreased liver function.
Liver damage occurring due to disorder of the bile ducts (biliary cirrhosis).
Gall bladder disease.
Long-term (chronic) or sudden (acute) inflammation of the pancreas (pancreatitis), except when this is a result of very high triglyceride levels (hypertriglyceridaemia).
Pregnancy.
Breastfeeding.
People who have ever had a skin reaction to UV light while taking other fibrate medicines or ketoprofen.
Allergy to peanut (arachis) oil, soya lecithin or related products.
Rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption (Supralip tablets contain lactose).

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
The safety of this medicine during pregnancy has not been established. It should not be used by pregnant women. Seek further medical advice from your doctor.
It is not known if this medicine passes into breast milk. For this reason, the manufacturer states that it should not be used by women who are breastfeeding. Seek medical advice from your doctor.

Label warnings
Take this medication with or after food.

Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.
Disturbances of the gut such as diarrhoea, flatulence, nausea, vomiting or abdominal pain.
Headache.
Fatigue.
Balance problems involving the inner ear (vertigo).
Skin reactions such as rash and itch.
Abnormal reaction of the skin to light, usually a rash, redness or blistering (photosensitivity).
Inflammation of the pancreas (pancreatitis).
Abnormal blood clot in a blood vessel, eg in the leg (deep vein thrombosis) or lungs (pulmonary embolism).
Hair loss (alopecia).
Sexual problems.
Alteration in results of liver function tests.
Gallstones.
Muscle pain, inflammation, cramps or weakness.
Muscle breakdown (rhabdomyolysis).
Inflammation of the liver (hepatitis).

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.

There is an increased risk of side effects on the muscles (myopathy) if fenofibrate is taken in combination with other fibrate medicines, or statins used for lowering cholesterol such as simvastatin. These should be used with caution with fenofibrate. If you are taking another fibrate or a statin in combination with this medicine you should inform your doctor immediately if you experience any muscular symptoms (see warning above).

Fenofibrate increases the anti-blood-clotting effect of anticoagulant medicines such as warfarin, thus increasing the risk of bleeding. For this reason, if you are taking an anticoagulant medicine your doctor may need to decrease your dose when you start taking fenofibrate as well. Your blood clotting time (INR) should be regularly monitored so that your anticoagulant dose can be adjusted as necessary.

If you take fenofibrate in combination with the immunosuppressant medicine ciclosporin, there may be a risk of a decline in your kidney function. For this reason, people taking both these medicines should have their kidney function closely monitored.

Fenofibrate may enhance the blood sugar lowering effects of insulin and sulphonylurea medicines for diabetes, such as glibenclamide or gliclazide. If you are taking one of these medicines to control diabetes, you should be aware that fenofibrate may cause unpredictable drops in your blood sugar and your doctor may need to reduce your dose of antidiabetic medicine.

Other medicines containing the same active ingredient
Fenogal 
Lipantil micro  
Fenofibrate capsules are also available without a brand name, ie as the generic medicine.

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件(201232922531324.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------

更新日期: 2012-3-30
附件:
 
调控比例: 100%
订购表单下载
Copyrights © 2010,2011,2012 www.ShiJieBiaoPin.com, Inc., All rights Reserved www.ShiJieBiaoPin.com, Inc.
客服工作时间:太平洋时间18:00-24:00
国内客服电话:     国际免费电话:
友情提示:以上电话为免费电话,无需您承担任何费用,世界标品提供中文客服,请您放心拨打!
电子邮箱:sciteck.hongkong@gmail.com, 15901965168@163.com