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  药店国别: 美国药房
产地国家: 美国
所属类别: 神经系统药物->精神障碍抑郁
处方药:处方药
包装规格: 1毫克/片 100片/瓶
计价单位:
   
生产厂家中文参考译名:
Caraco
生产厂家英文名:
Caraco
该药品相关信息网址1:
http://www.drugs.com/pro/hydergine.html
原产地英文商品名:
ERGOLOID MESYLATES(HYDERGINE GENERIC) 1MG/TAB 100TABS/BTL
原产地英文药品名:
ERGOLOID MESYLATES
中文参考商品译名:
甲磺酸双氢麦角碱(喜得镇仿制药) 1毫克/片 100片/瓶
中文参考药品译名:
甲磺酸双氢麦角碱
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Mental degradation
英文适应病症2:
Acute and chronic cerebrovascular disease sequelae function, mental deterioration
英文适应病症3:
Mild to moderate vascular dementia
英文适应病症4:
Vascular headache
临床试验期:
完成
中文适应病症参考翻译1:
精神退化
中文适应病症参考翻译2:
急慢性脑血管病后遗的功能、智力减退
中文适应病症参考翻译3:
轻中度血管性痴呆
中文适应病症参考翻译4:
血管性头痛
药品信息:

友情提示:Hydergine brand discontinued,Only the generic is available。Hydergine品牌藥已停产,只有仿制药。

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 详细处方信息以本药内容附件PDF文件(2011121817440733.PDF,2011121817440025.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------
部分中文喜得镇处方资料(仅供参考)

英文药名: Hydergine (Ergoloid Tablets)

中文药名: 喜得镇(双氢麦角胺片)

药物名称
【药物名称】喜得镇
【通 用 名】甲磺酸双氢麦角碱片
【主要成分】甲磺酸双氢麦角碱

生产厂家
Novartis 诺华

药理毒理
动物试验表明甲磺酸双氢麦角碱改变脑的神经传递,有资料表明它对多巴胺受体有激动效应和对肾上腺受体有阻断效应。它改善受损害的抱代谢功能,并缩短脑循环时间,此效应反映在脑的电活性的改变,在脑电图的功率谱上有显著变化。

药代动力学
口服甲磺酸双氢麦角碱片后,吸收量达25%,在0.5-1.5小时之间达到最大血浆浓度,由于首过效应,生物利用度在5-12%之间,分布量为1100L,血浆蛋白结合率为31%,消除为双相;甲磺酸双氢麦角碱主要随胆汁经粪便排泄,尿中以原型药及其代谢物形式排除原药物的2%,而原型药物不到1%。全部清除率约为1800ml/min.老年患者的血浆浓度比年青患者稍高。有肾功能障碍的病人几乎无必要减少计量,因为仅有少量的药物是通过肾脏代谢的。

适 应 症
1、主要用于改善与老年化有关的精神退化的症状和体征。
2、急慢性脑血管病后遗的功能、智力减退的症状。
3、轻中度血管性痴呆。
4、血管性头痛。

用法用量
口服。一次1-2mg一日3-6mg;饭前服用,疗程遵医嘱。

不良反应
偶可发生鼻塞、短暂的恶心和胃不适,但通常将本药与食物同服可防止。大多数病例不需要采取特殊措施,副作用即可消失。必要时可调整剂量。

禁 忌
1、对本品有过敏史者禁用。
2、严重心脏病患者,特别是伴有心动徐缓者应禁用。

注意事项
1、心律稍慢者应慎用。
2、注意不要与多巴胺类药物合用。

What is Hydergine?
Hydergine is a Nootropic that is derived from rye and it has become one of the world's most useful and popular "smart drugs". Created in the 1940's hydergine is a widely used drug throughout the world for a number of treatments and reasons including age-causing cognitive decline, memory enhancement, learning, concentration, raising dopamine levels and as a powerful antioxidant.

Hydergine is one of the most tested products ever developed and it is extremely non-toxic and has very few side-effects. As proven in numerous studies, Hydergine offers many brain-boosting and anti-aging benefits.

Many studies have shown Hydergine's ability to balance or stabilize the brain's oxygen levels, so if brain's oxygen levels are too low then Hydergine will raise them and if too high then Hydergine will lower them. Sometimes Hydergine is used before surgery or after strokes, hemorrhages, certain accidents and heart attacks. Other studies suggest that Hydergine may be able to help reverse damage to brain cells.

It was in the 1940's that a considerable amount of research went into Hydergine, especially as studies started to uncover its enhancing effects on cognition. It was developed due to its ability to control geriatric disorders by improving peripheral circulation and cerebral function in fact Hydergine was the first drug to work as an effective treatment for Alzheimer's disease and senile dementias.

70 years on and Hydergine is used all around the world treating a wide variety of conditions including age-related cognitive decline all with a plethora of anti-aging, brain-enhancing benefits. As you would imagine for a product which has been in circulation for such a long time, Hydergine is one of the most tested pharmaceuticals ever developed.

Hydergine can enhance memory and learning whilst improving cognitive abilities, such as concentration and recall along with its property to help in the prevention of damage to brain cells caused by hypoxia or insufficient oxygen. Some studies have even suggested that Hydergine may even be able to help reverse existing damage to brain cells. Hydergine is a vasodilator increasing blood flow and oxygen levels in the brain and enhances the metabolism of brain cells and it has shown to increase the volume while reducing the size of mitochondria - the power houses which produce ATP (energy). It also improves the uptake of glucose which is necessary for brain energy and assists in the reduction of the age-related toxin lipofuscin.

Brain-derived neurotrophic factor, known as BDNF, is involved in the growth of neurons and neuritis as well as in their repair when damaged. Hydergine stimulates new interconnective growth between neurons which causes the release of BDNF. As we age neurons get disconnected as the brain produces less and less BDNF. Hydergine copies the effect of nerve growth factor which stimulates the growth of new dendrites which are at the receiving ends of brain cells. Dendrites usually decline with aging. This is an important mechanism which, in the elderly, may enhance memory and learning. With various neuroscientists believing that there is a correlation between the number of interneural connections (dendrites) in the brain and intelligence, Hydergine increases the cortical thickness and raises the levels of the neurotransmitter dopamine.

Hydergine has a remarkable ability to stabilize the oxygen levels in the brain. Oxygen is unique in that it can produce free radicals and be a free radical scavenger. At optimum, balanced levels oxygen kills more free radicals than it produces but with either too much or too little oxygen it creates them, which in turn can lead to aging. Should the brains oxygen levels be too low then Hydergine raises them and vice versa. In some European countries Hydergine is used pre-operatively and after heart attacks, hemorrhages and after strokes in order to gain some extra time. Hydergine is also a drug of choice when dealing with certain accidents like electrocution or drowning.

Hydergine can normalize systolic blood pressure and has also been shown to lower very high cholesterol levels as well as reduce the symptoms of lethargy. As with other so- called "smart drugs", a feeling of brain-awakening is often expressed.

Some people need to take Hydergine for several months before any significant effects are felt and often when first using Hydergine people can draw to the conclusion that it is not very effective. Some studies were showing mild, less dramatic effects and this lead to many physicians, particularly in Europe, to draw to the conclusion that the dosage was too low. The U.S. recommended dose is 3 mg. per day, while the European recommended dose is 9 mg. per day in 3 divided doses. Most people find the most suitable dosages to be around 2.25mg to 4.5mg per day with occasional breaks.

Hydergine is extremely nontoxic and has very few side-effects, however, Hydergine may initially cause some mild nausea, gastric disturbances and bradycardia. It is contraindicated for people who are allergic to it, who suffer from psychosis, or who have an abnormally slow heartbeat or low blood pressure. Combining Hydergine with other ergot derivatives (such as Nicergoline or the more potent Bromocriptine) or other cognitive enhancers may (probably will) have a synergistic effect, so you may need to scale down the dosages of all the drugs. One should seek the advice of a physician when combining Hydergine with other cognitive enhancers especially if taking at a dosage higher than 9 mg. per day. The most common side effect is stomach upset. This can be avoided by using specially coated (FAS) tablets or by using a sublingual liquid preparation.

With its beneficial affects, mild side effects and few contraindications, Hydergine must surely rank as one of the most important anti-aging medicines available today.

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 详细处方信息以本药内容附件PDF文件(2011121817440733.PDF,2011121817440025.pdf)的“原文Priscribing Information”为准
---------------------------------------------------------------

更新日期: 2014-08-14
附件:
2011121817440733.PDF    

2011121817440025.pdf    

 
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