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当前本网站药物产品种数共 8524 处方药 8148 非处方药 269 保健品/医疗用具 107

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  药店国别: 美国药房
产地国家: 美国
所属类别: 眼科药物->缩瞳药
处方药:处方药
包装规格: 4克/管
计价单位:
  点击放大  
生产厂家中文参考译名:
爱尔康
生产厂家英文名:
ALCON
该药品相关信息网址1:
http://www.drugs.com/pro/pilopine-hs.html
该药品相关信息网址2:
http://www.rxlist.com/pilopine_hs-drug.htm
该药品相关信息网址3:
http://www.drugs.com/cdi/pilopine-hs-gel.html
原产地英文商品名:
PILOPINE HS 4% EYE GEL 4g/tube
原产地英文药品名:
PILOCARPINE HYDROCHLORIDE
中文参考商品译名:
PILOPINE HS 4%眼用凝胶 4克/管
中文参考药品译名:
盐酸毛果芸香碱
曾用名:
匹鲁卡品
原产地国家批准上市年份:
1984/10/01
英文适应病症1:
Miosis
英文适应病症2:
Lowering intraocular pressure
临床试验期:
完成
中文适应病症参考翻译1:
缩瞳
中文适应病症参考翻译2:
降眼压
药品信息:

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 详细处方信息以本药内容附件PDF文件(2011112717284316.pdf)的“原文Priscribing Information”为准
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部分中文Pilopine HS处方资料(仅供参考)

英文药名: Pilopine HS (pilocarpine Gel)

中文药名: 毛果芸香碱眼用凝胶

药品简介
毛果芸香碱眼凝胶属化药新药5类。 作为眼科局部应用的缩瞳药,毛果芸香碱属拟胆碱药,它直接作用于M-胆碱受体产生毒蕈碱样作用。
作用机理:
1、作用于瞳孔括约肌,引起缩瞳,牵引巩膜小梁,拉开虹膜根部,开放房角使房水流畅而降低眼压。
2、作用于睫状体使其收缩,牵引巩膜,扩大巩膜小梁网眼,改善房水外流而降低眼压。
临床利用其缩瞳、降眼压作用治疗开角型青光眼和闭角型青光眼。
青光眼的发病率和患病率较高,在眼科的门诊病人中占8.5%。因此,开发研制新的治疗青光眼的药物制剂具有较大的市场空间。毛果芸香碱用于治疗青光眼已有100多年的历史,虽然近年来,国内外相继开发出几种新的治疗青光眼的药物(噻吗心安、碳酸酐酶抑制剂等),但因副作用较大,或药物的价格昂贵,使其应用受到限制,而毛果芸香碱因疗效好、价格低廉,目前仍是大多数医生作为治疗青光眼的首选药物。
但由于其滴眼液在治疗时,作用时间较短,每天需要多次用药,因有缩瞳及增强调节作用,白天常引起瞳孔大小和屈光度波动,存在较大的局限性,因此它的使用也受到限制。
国外早在二十世纪70年代就开始了毛果芸香碱新剂型的研究,现在已经有凝胶剂和眼用植入剂等新剂型上市。国内对毛果芸香碱的制剂研究很少,现在仍然只有滴眼液一个眼用品种,制剂的品种单一,极大地限制了毛果芸香碱的临床应用。为此,研究开发了硝酸毛果芸香碱眼凝胶。
硝酸毛果芸香碱眼凝胶,选择卡波沫为凝胶基质。作为一种药用辅料,卡波沫在国外已应用多年,具有释药快、药效持久、无油腻性、易涂展、粘附性好、对皮肤及粘膜无刺激等特点,已被中国药典2000年版收载。硝酸毛果芸香碱眼凝胶与硝酸毛果芸香碱滴眼液比较,具有在眼内停留时间长,具缓释效果,副作用小,给药方便,患者耐受性好等特点。
国外对于毛果芸香碱眼用凝胶的研究开展得较早,1996年Alcon公司就分别在美国和英国上市了该制剂,美国上市的商品名为Pilopine HS,英国上市的商品名为Pilogel。本品原料药已被中国药典2000版收载;国内仅有滴眼液用于治疗青光眼,为治疗青光眼的首选一线用药,临床用量居各类抗青光眼药物的前列;近年又有片剂批准上市,但其适应症为治疗癌症患者放化疗引起的口干,未见有其他的剂型被批准进行临床研究或生产。 目前我们已获得SDA签发的临床批件。

Pilopine HS Gel
Pronunciation: pye-loe-KAR-peen
Generic Name: Pilocarpine
Brand Name: Pilopine HS

Pilopine HS Gel is used for:
Treating certain types of glaucoma (increased pressure in the eye) alone or in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Pilopine HS Gel is a direct-acting miotic. It works by lowering the fluid pressure inside the eyeball by increasing fluid drainage from the eyeball. It also causes the pupils to constrict or get smaller (miosis).

Do NOT use Pilopine HS Gel if:
•you are allergic to any ingredient in Pilopine HS Gel
•you have a certain type of glaucoma (eg, pupillary block glaucoma), eye inflammation, or a severe eye infection

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pilopine HS Gel:
Some medical conditions may interact with Pilopine HS Gel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
•if you are pregnant, planning to become pregnant, or are breast-feeding
•if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
•if you have allergies to medicines, foods, or other substances
•if you have a detached retina, an eye infection, asthma, or chronic obstructive pulmonary disease
•if you have had a heart attack

Some MEDICINES MAY INTERACT with Pilopine HS Gel. However, no specific interactions with Pilopine HS Gel are known at this time.

Ask your health care provider if Pilopine HS Gel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pilopine HS Gel:
Use Pilopine HS Gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.
•Pilopine HS Gel is only for the eye. Do not get it in your nose or mouth.
•Pilopine HS Gel may be used around the eye or in the eye. To use Pilopine HS Gel in the eye, first, wash your hands. Using your index finger, pull the lower eyelid away from your eye to form a pouch. Squeeze a thin strip of ointment into the pouch. After using Pilopine HS Gel, gently close your eyes for 1 to 2 minutes. Wash your hands to remove any medicine that may be on them. Wipe the applicator tip with a clean, dry tissue.
•To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.
•If you miss a dose of Pilopine HS Gel, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Pilopine HS Gel.

Important safety information:
•Pilopine HS Gel may cause blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Pilopine HS Gel with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
•Pilopine HS Gel may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
•PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Pilopine HS Gel while you are pregnant. It is not known if Pilopine HS Gel is found in breast milk. If you are or will be breast-feeding while you use Pilopine HS Gel, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Pilopine HS Gel:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Blurred vision; change in vision; eye irritation; eyelid twitching; headache at the temples or around the eyes; increased tearing; nearsightedness; redness or swelling of the eye; temporary stinging or burning.

Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); detachment of the retina; poor vision at night.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include asthma; blurred vision; diarrhea; fainting; increased saliva; increased sweating; irregular heartbeat; low blood pressure; nausea; slow pulse; tremor; vomiting.

Proper storage of Pilopine HS Gel:
Store Pilopine HS Gel between 36 and 80 degrees F (2 and 27 degrees C). Store away from heat, moisture, and light. Do not freeze. Do not store in the bathroom. Keep Pilopine HS Gel out of the reach of children and away from pets.

General information:
•If you have any questions about Pilopine HS Gel, please talk with your doctor, pharmacist, or other health care provider.
•Pilopine HS Gel is to be used only by the patient for whom it is prescribed. Do not share it with other people.
•If your symptoms do not improve or if they become worse, check with your doctor.
•Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Pilopine HS Gel. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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 详细处方信息以本药内容附件PDF文件(2011112717284316.pdf)的“原文Priscribing Information”为准
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更新日期: 2011-11-28
附件:
 
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