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 详细处方信息以本药内容附件PDF文件（201151701565015.pdf）的“原文Priscribing Information”为准
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部分中文盐酸咪达唑仑处方资料（仅供参考）

英文名称: Midazolam hydrochloride

英文同义词: rocam;versed;hypnovel;ro21-3981/003;MIDAZOLAM HCL;MIDAZOLAM HYDROCHLORIDE;MIDAZOLAM HYDROCHLORIDE, DEA SCHEDULE III;5-a)(1,4)benzodiazepine,8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo(hy;8-chloro-6-(2-fluorophenyl)-1-methyl-4h-imidazo(1,5-a)(1,4)benzodiazepinehyd;8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL-4H-IMIDAZO[1,5A][1,4]BENZODIAZEPINE HYDROCHLORIDE

中文名称: 盐酸咪达唑仑

中文同义词: 盐酸咪达唑仑;8-氯-6-(2-氟苯基)-1-甲基-4H-咪唑并[1,5a][1,4]苯并二氮杂卓盐酸盐

其他名称：Dormicium、Hypnovel、咪哒唑仑、咪唑安定、咪唑二氮卓、盐酸咪达唑仑、马来酸咪达唑仑、R。-21-3981、Sorenor、多美康(Dormicum)、力月西、速眠安(Dormicum)。 

药理作用：本品属于苯二氮卓咪唑衍生物，为速效睡眠诱导剂，亲脂性强，微溶于水。本品稳定性强，耐受性好。其作用迅速，药物在体内很快被代谢成无活性物，所以作用时间短，可产生抗焦虑、镇静、催眠、抗惊厥及肌肉松驰作用，静脉或肌肉注射后，会产生短暂的顺行性记忆丧失(药物作用时间内，病人无法记忆当时情况)，可增强其他麻醉药的镇痛作用。本品口服或肌注均吸收迅速而完全，可分布全身，注射开始大约2分钟后即可生效。经肝脏代谢或与葡萄糖醛酸结合而失活，自肾脏排出，其分布相半衰期为10分钟，消除相半衰期为1.5-2.5小时。 

临床应用：用于催眠、麻醉前给药或全麻诱导。 

禁忌症：对苯二氮卓过敏患者禁用。 

不良反应：不良反应少见。可抑制呼吸，其程度与剂量成正比。可使心率增快、周围血管阻力下降。 
 
注意事项：
(1)对老年或呼吸功能不全的患者，在静注给药时速度过快或剂量过高时，可出现窒息或呼吸抑制故应慎用。对器质性脑病变、呼吸功能有损害的老年患者，剂量应慎重决定，与每个患者有关的特定因素应考虑。
(2)本品可透过胎盘，但量较小。妊娠初期3个月内的妇女、重症肌无力患者禁用。
(3)精神分裂症或严重抑郁患者不宜首选本品作为催眠药。
(4)服用本品后4-6小时不宜驾车或操作重型机器，以免发生危险。
(5)本品可增强中枢抑制药的作用。不能与硫喷妥钠混合使用。与乙醇合用也可增强作用，故注射本品12小时内不得饮用含乙醇的饮料。
(6)肌注后易吸收，静注对局部刺激作用较轻。 

What Is Versed?
Versed® (midazolam) is a prescription medication approved for use as a sedative, anxiety, or anesthesia medication used before or during surgeries, medical procedures, or dental procedures. It is also used to sedate people on respirators in intensive care units.
 
(Click Versed Uses for more information on what the drug is used for, including possible off-label uses.)
 
Who Makes Versed?
Brand-name Versed was made by Hoffmann-La Roche, but it is no longer manufactured. Fortunately, there are several companies that make generic Versed.
 
How Does It Work?
Versed is part of a group of medicines called benzodiazepines. Benzodiazepines have several effects on the body, including:
Reducing anxiety
Causing sleepiness
Relaxing the muscles
Stopping seizures
Impairing short-term memory.
 
All benzodiazepines can have these effects to some degree, depending on the specific benzodiazepine that is being taken. They work in the brain by enhancing the effects of gamma-aminobutyric acid (GABA), a brain chemical that is naturally calming. GABA can slow down or stop certain nerve signals in the brain. This is why Versed and other benzodiazepines are known as mild tranquilizers, sedatives, or central nervous system depressants (CNS depressants).
 
Because Versed is very fast acting, it is particularly useful for anesthesia. It can help start the anesthesia process (called anesthesia induction), relieving anxiety and causing memory loss (amnesia). In fact, many people who use Versed for "conscious sedation" during a procedure are awake for the entire procedure but remember nothing, often believing they were "out" the whole time.

When and How to Take Versed
Some general considerations for when and how to take the medication include the following:
Versed comes in two forms -- an injectable form and a syrup form. The syrup form is meant for children who do not need an IV for any other reason (and who are likely to be afraid of an IV injection).
Because Versed is typically used before a surgery or procedure, you may need to have an empty stomach. Before your surgery or procedure, be sure to ask your healthcare provider for instructions.
For the drug to be used safely, your healthcare provider must be equipped with the training and equipment necessary to handle breathing problems that Versed can cause. Ask your healthcare provider if he or she is prepared to handle a breathing problem or emergency, especially if Versed will be used in a clinic or office setting (such as a dentist office), rather than in the hospital.
 
Dosing Information
The dosage that your healthcare provider recommends will vary depending on a number of factors, including:
Your age and weight
The degree of sedation, amnesia, or anesthesia desired
Other medications you may be taking
Other medical conditions you may have.
 
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Side Effects
As with any medicine, side effects are possible with Versed. However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Serious side effects are less common.
 
Common side effects of Versed include, but are not limited to:
Breathing problems
Tenderness at the injection site or pain when Versed is injected (for the injection form)
Nausea and vomiting (for the syrup form).
 
Drug Interactions With Versed
Versed can potentially interact with a few other medicines (see Versed Drug Interactions).
 
What Should I Tell My Healthcare Provider?
You should talk with your healthcare provider prior to taking this medication if you have:
Glaucoma
Chronic obstructive pulmonary disease (COPD)
Any allergies, including allergies to food, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
Pregnant or thinking of becoming pregnant
Breastfeeding.
 
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

What If I Take an Overdose?
People who take too much Versed may have overdose symptoms that could include:
Confusion
Drowsiness
Coordination problems
Difficulty breathing
Coma
Slow reflexes.
 
If you happen to overdose, seek immediate medical attention.

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 详细处方信息以本药内容附件PDF文件（201151701565015.pdf）的“原文Priscribing Information”为准
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