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  药店国别: 美国药房
产地国家: 美国
所属类别: 心血管系统药物->心脏病
处方药:处方药
包装规格: 200毫克/丸 100丸/盒
计价单位:
   
该药品相关信息网址1:
http://www.drugs.com/mtm/anturane.html
该药品相关信息网址2:
http://www.drugs.com/pro/anturane.html
该药品相关信息网址3:
http://www.rxlist.com/anturane-drug.htm
原产地英文商品名:
SULFINPYRAZONE 200mg/pill 100pills/box
原产地英文药品名:
SULFINPYRAZONE
中文参考商品译名:
苯磺唑酮 200毫克/丸 100丸/盒
中文参考药品译名:
苯磺唑酮
原产地国家批准上市年份:
0000/00/00
英文适应病症1:
Ischemic heart disease
英文适应病症2:
Cerebrovascular disease
英文适应病症3:
Complications of valvular heart disease, arterial embolism
英文适应病症4:
Gout
英文适应病症5:
Hyperuricemia
临床试验期:
完成
中文适应病症参考翻译1:
缺血性心脏病
中文适应病症参考翻译2:
脑血管疾病
中文适应病症参考翻译3:
瓣膜性心脏病动脉栓塞并发症
中文适应病症参考翻译4:
痛风
中文适应病症参考翻译5:
高尿酸血症
药品信息:

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 详细处方信息以本药内容附件PDF文件(20115419252424.pdf)的“原文Priscribing Information”为准
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部分中文苯磺唑酮处方资料(仅供参考)

分类名称
一级分类:内分泌系统药物 二级分类:痛风及高尿酸血症用药物 
 
药品英文名
Sulfinpyrazone
 
药品别名
苯磺唑酮、苯磺保泰松、硫氧唑酮、磺吡拉宗、磺胺吡啶二酮、亚磺基吡唑酮、亚硫吡拉宗、Anturane
 
药物剂型
片剂:100mg, 0.2g。
 
药理作用
本品为保泰松的衍生物。在体内具有抑制血小板聚集和释放的作用,能可逆性地抑制血小板前列腺合成酶。本品可竞争性抑制尿酸盐在近曲小管的主动重吸收,增加尿酸的排泄,降低血中尿酸的浓度,减缓或预防痛风结节形成和关节的痛风病变。本品还可抑制血小板聚集,增加血小板存活时间。还具有微弱的抗炎和镇痛作用。
 
药动学
本品口服吸收良好,健康人每次口服200mg,服后1h达峰值,t1/23.3h,AUC每分钟3.0mg/ml,每分钟CL70ml,Vd18L。大部分以原形从肾脏排泄。
 
适应证
主要用于缺血性心脏病和脑血管疾病的防治,如冠状动脉粥样硬化性心脏病、心肌梗死、暂时性脑缺血发作和脑梗死等;也用于防止瓣膜性心脏病动脉栓塞并发症及手术后静脉血栓形成的预防。用于慢性痛风的治疗。也可用于高尿酸血症。
 
禁忌证
有严重肝肾功能不全者禁用。
 
注意事项
1.血液病、溃疡病和肾结石者慎用。
2.服药初期宜加用苏打片,服药期间应忌酒和多饮水。
3.定期随访血象、血尿酸和肾功能。个别患者用药期间可引起肾功能衰竭。
4.孕妇、肾功能不全者慎用。
 
不良反应
主要为胃肠反应,如恶心、呕吐、腹泻等,发生率10%~15%。偶见溃疡发生,也有报道发生血小板和粒细胞减少。
 
用法用量
口服,每天2次,每次100~200mg,逐渐增加剂量至每次200~400mg,持续1周。维持量每天2次,每次100~400mg。进餐时或与牛奶同时服用。
 
药物相应作用
1.与阿司匹林等水杨酸类药物:(1)阿司匹林等可抑制尿酸排泄,故合用可降低磺吡酮的排尿酸作用。用于治疗痛风时,两药不宜合用;(2)两药合用抗血小板聚集作用可增强。磺吡酮可通过抑制环氧化酶,激发阿司匹林诱发哮喘患者的支气管痉挛。
2.与吲哚美辛合用可增强吲哚美辛作用。
3.与噻嗪类利尿药氢氯噻嗪、苄氟噻嗪等噻嗪类利尿药能提高尿酸的血浆浓度,因而对抗磺吡酮的抗痛风效果。
4.与糖皮质激素合用使磺吡酮的作用增强。
5.与丙磺舒合用增加对治疗慢性痛风的疗效。
6.与青霉素类及头孢菌素类抗生素合用可增加青霉素G、邻氯西林、萘夫西林等青霉素类抗生素以及头孢氨苄、头孢拉定等头孢菌素类抗生素的作用。
7.可增强香豆素类抗凝药的作用,合用时需减少后者的剂量。
8.可降低青霉素、甲苯磺丁脲的清除率,后者的血药浓度被增高并延长其作用持续时间。
 
专家点评
本品是保泰松衍生物。具有类似阿司匹林的作用,抑制血小板的环氧化酶,能延长血小板存活期,减慢血小板更新、抑制血小板黏附和聚集,因此具有较强的抗栓性能。主要用于急性心肌梗死的二级预防,可降低猝死的危险,降低再梗死率。也用于脑血管患者。临床用于慢性痛风,能减慢或强防痛风结节的形成和关节的痛风病变。现本品也用于缺血性心脏病,临床研究表明,它能显著减少新近发生心肌梗死患者在第一年内病死率,减少心绞痛及心肌梗死的发病率。也用于脑血管疾病,防止血栓形成。

Anturane
Generic Name: sulfinpyrazone (sul fin PEER a zone)
Brand Names: Anturane

What is Anturane (sulfinpyrazone)?
Sulfinpyrazone reduces the amount of uric acid in your body by causing more uric acid to be passed out in your urine. Sulfinpyrazone also has other effects in the body that are important in the treatment of gout.

Sulfinpyrazone is used to treat gout and gouty arthritis.

Sulfinpyrazone may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Anturane (sulfinpyrazone)?
To reduce the risk that kidney stones will form, drink at least 8 to 10 full glasses (8 ounces) of fluid every day, unless your doctor tells you not to. Take sulfinpyrazone with food, milk, or an antacid to lessen stomach upset. Do not take aspirin, salsalate (Disalcid), magnesium salicylate (Magan, Doan's), choline and magnesium salicylate (Trilisate), or other aspirin-like products without the approval of your doctor. These products decrease the effects of sulfinpyrazone. Taking one aspirin a day to reduce the risk of a heart attack is usually acceptable. Talk to your doctor.

Who should not take Anturane (sulfinpyrazone)?
Before taking this medication, tell your doctor if you
have ever had an allergic reaction to sulfinpyrazone,
have kidney disease or poorly functioning kidneys,
have kidney stones,
have an ulcer in your stomach,
have blood problems, or
are on high-dose aspirin or salicylate therapy.

Sulfinpyrazone is in the FDA pregnancy category C. This means that it is not known whether sulfinpyrazone will harm an unborn baby. Do not take sulfinpyrazone without first talking to your doctor if you are pregnant. It is also not known whether sulfinpyrazone passes into breast milk. Do not take sulfinpyrazone without first talking to your doctor if you are breast-feeding a baby.

How should I take Anturane (sulfinpyrazone)?
Take sulfinpyrazone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose of sulfinpyrazone with a full glass of water. Also, to reduce the risk that kidney stones will form, drink at least 8 to 10 full glasses (8 ounces) of fluid every day, unless your doctor tells you not to. Take sulfinpyrazone with food, milk, or an antacid to lessen stomach upset. If nausea, vomiting, or loss of appetite is severe or persistent, consult your doctor.
Do not stop taking this medication without the approval of your doctor.

Store sulfinpyrazone at room temperature away from moisture and heat.

What happens if I miss a dose?
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take only your next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?
Seek emergency medical attention.

Symptoms of a sulfinpyrazone overdose include nausea, vomiting, diarrhea, stomach pain, poor coordination, difficulty breathing, seizures, and coma. An overdose of sulfinpyrazone can result in death.

What should I avoid while taking Anturane (sulfinpyrazone)?
Do not take aspirin, salsalate (Disalcid), magnesium salicylate (Magan, Doan's), choline and magnesium salicylate (Trilisate), or other aspirin-like products unless your doctor approves. These products decrease the effects of sulfinpyrazone. Taking one aspirin a day to reduce the risk of a heart attack is usually acceptable.

Follow your doctor's recommendations about diet.

Anturane (sulfinpyrazone) side effects
Stop taking sulfinpyrazone and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Heartburn, nausea, and upset stomach are the most common side effects of sulfinpyrazone therapy. Take each dose with food, milk, or an antacid to decrease these side effects.

Contact your doctor as soon as possible if you experience an acute attack of gouty arthritis.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Anturane (sulfinpyrazone)?
Do not take aspirin, salsalate (Disalcid), magnesium salicylate (Magan, Doan's), choline and magnesium salicylate (Trilisate), or other aspirin-like products unless your doctor approves. These products decrease the effects of sulfinpyrazone. Taking one aspirin a day to reduce the risk of a heart attack is usually acceptable.

The combination of sulfinpyrazone and acetaminophen (in Tylenol and many other products) can be damaging to your liver. Do not take products that contain acetaminophen unless your doctor approves.

Sulfinpyrazone may increase the effects of the following medicines:
warfarin (Coumadin), which could lead to bleeding; and
tolbutamide (Orinase), which could lead to low blood sugar levels.

You may need lower doses of these drugs.

Sulfinpyrazone may decrease the effects of other medicines:
theophylline (Theo-Dur, Theochron, Theolair, Elixophylline, others), which could lead to worsening asthma or chronic obstructive pulmonary disease (COPD); and
verapamil (Verelan, Calan, Isoptin), which could lead to worsening heart problems such as high blood pressure or an irregular heartbeat.

You may need higher doses of these drugs.

Niacin (Nicolar, Nicobid, others) may decrease the effects of sulfinpyrazone. A dose adjustment may be necessary.

Drugs other than those listed here may also interact with sulfinpyrazone. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Compare Anturane with other medications
Gouty Arthritis

Where can I get more information?
Your pharmacist has more information about sulfinpyrazone written for health professionals that you may read.

What does my medication look like?
Sulfinpyrazone is available with a prescription generically and under the brand name Anturane. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.
Anturane 100 mg--white, round, scored tablets
Anturane 200 mg--green capsules

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 详细处方信息以本药内容附件PDF文件(20115419252424.pdf)的“原文Priscribing Information”为准
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更新日期: 2011-5-5
附件:


20115419252424.pdf    

 
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