友情提示：美国FDA 批准了 Jenloga ，然后研究者将该药卖给了药厂Shionogi ，后者又将Jenloga 改名为Kapvay。所而Kapvay 就是Jenloga.  成分完全一样。

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件（201132721470519.pdf）的“原文Priscribing Information”为准
---------------------------------------------------------------
部分中文盐酸可乐定处方资料（仅供参考）

盐酸可乐定缓释片（Kapvay,Shionogi Inc）

制造商：
盐野义制药公司

药理分类：
中央alpha2 -受体激动剂。

活性成分：
盐酸可乐定为0.1mg，为0.2mg;分机- REL的标签。

指示：
注意缺陷多动障碍（ADHD）。

药理作用：
这可乐配方的适应症为治疗多动症患者，不论是单一治疗或辅助治疗，以兴奋剂药物。它没有被研究与多动症的成年人。 可乐定行动多动症的治疗机制尚不清楚。除了在多动症的影响，它减少了从大脑交感神经流出，在周边血管阻力，肾血管阻力，心率和血压下降造成的。

其他形式的可乐定用于治疗高血压的成年人，但这些配方不可以互换。

临床试验：
该Kapvay在儿童和青少年患有ADHD疗效成立于二安慰剂对照试验。对于这两个试验中，主要疗效分析治疗组之间变化的比较基准分数一周的ADHDRS - 5级总成绩第四。

研究1是一个8周的随机，双盲固定剂量的6-17岁的患者单一治疗研究。患者被随机分配到Kapvay 0.2mg/day，Kapvay 0.4mg/day，或安慰剂。继滴定至目标剂量，病人均保持在该剂量至少2周，然后下降到0.1mg/day锥形在治疗的最后一周。对于Kapvay两种剂量，在ADHD症状的改善有统计学相比，安慰剂组Kapvay显着性。

研究二是8周，随机，双盲，安慰剂控制的儿童和青少年灵活的剂量研究谁已治疗4周时使用精神兴奋剂和不充分的反应。患者随机接受Kapvay +兴奋剂（哌甲酯或安非他明），或单独兴奋剂。 Kapvay剂量滴定至0.4mg/day超过耐受性和反应的基础上3周的时间。这项研究的剂量维持2周前锥形0.1mg/day用于治疗的最后一周。患者由于Kapvay组合+兴奋剂有所改善兴奋剂相比，那些在5周后单独多动症评分。

成人：
不推荐。

儿童：
<6岁：不推荐。燕子的整体。滴定的反应。最初为0.1mg睡前1周，然后为0.1mg每日两次，1周，然后在早上为0.1mg和0.2mg睡前1周，然后为0.2mg，每日两次。逐步撤出，减少了在3-7天的时间间隔0.1mg/day。肾功能障碍：可能需要降低剂量。

警告/注意事项：
低血压。心动过缓。心脏传导阻滞。血管疾病。传导干扰。慢性肾功能衰竭。晕厥。严重的冠状动脉供血不足。最近的心肌梗塞。监测脉搏，血压。保持足够的水分。定期重新评估。妊娠（Cat.C）。哺乳的母亲。

互动：
Potentiates酒精，其他中枢神经系统抑制剂，抗高血压药。降血压作用，可拮抗三环抗抑郁药。添加剂房室传导阻滞，药物影响心脏传导（如洋地黄，钙通道阻滞剂，β-阻断剂）心动过缓。可乐定避免其他形式。可能需要调整药物剂量的并发兴奋剂。

不良反应：
嗜睡，疲劳，上呼吸道感染，烦躁，咽喉肿痛，失眠，做恶梦，情绪障碍，便秘，鼻塞，发热，口干，耳朵痛。

Generic Name:
Clonidine hydrochloride

Brand Names:
Kapvay

Kapvay Description:
Kapvay belongs to a class of drugs known as centrally acting alpha2-adrenergic agonists. The medication is used to treat attention deficit hyperactivity disorder (ADHD).

While Kapvay is not a central nervous system stimulant, the mechanism by which the medication helps treat ADHD is unknown.

Kapvay Side Effects:
Common side effects of Kapvay include:
Drowsiness
Fatigue
Upper respiratory tract infection
Irritability
Sore throat
Insomnia
Nightmares
Emotional disorder
Constipation
Nasal congestion
Increased body temperature
Dry mouth
Ear pain

For more information, see our Kapvay side effects page.

Kapvay Uses:
Kapvay is used to reduce certain behaviors commonly associated with ADHD. ADHD is characterized by inattention, hyperactivity and impulsive tendencies. The majority of patients diagnosed with ADHD are children; however, the condition can also affect adults.

Kapvay may be used alone or in conjunction with a psychostimulant. However, Kapvay should generally only constitute a single component of a larger ADHD treatment plan that includes social and educational elements.

Kapvay Interactions:
Kapvay may interact with the following medications and substances:
Alcohol
Barbiturates and other sedating drugs
Tricyclic antidepressants
Digitalis
Calcium channel blockers
Beta blockers
Other medications that contain clonidine (e.g. Catapres)
Medications for high blood pressure

Kapvay may interact with other medications or substances that are not listed above. In order to avoid potentially hazardous interactions, patients should talk with their doctor about the use of any other medicines, vitamins or supplements before beginning treatment with Kapvay.

Kapvay Dosage Information:
Typical Dosage Recommendations
Kapvay dosages may vary among patients. Your doctor will determine the size and frequency of your dosage according to your individual needs. Patients should follow the dosage guidelines established by their doctor.

Kapvay is administered in the form of an extended-release oral tablet and is available in 0.1 mg and 0.2 mg strengths. Kapvay should be swallowed whole and never crushed.

Patients normally begin treatment by taking 0.1 mg at bedtime. This dose may be gradually increased up to 0.4 mg per day as treatment progresses. Patients should eventually achieve a regimen in which they take a dose of Kapvay once in the morning and once at bedtime.

Patients should not abruptly stop taking Kapvay, unless otherwise instructed by their doctor. In order to prevent and reduce withdrawal symptoms, patients should undergo a gradual dose reduction when discontinuing use of the medication.

Missing a Dose of Kapvay
If you forget to take a dose of Kapvay, skip the missed dose and resume your normal dosage schedule. Do not consume a double dose of Kapvay to compensate for a missed dose.

Kapvay Overdose
An overdose of Kapvay may result in the following symptoms:
Changes in blood pressure
Slow heartbeat
Respiratory depression
Hypothermia
Drowsiness
Reduced reflexes
Weakness
Irritability
Constricted pupils

Patients should seek immediate medical attention if they have taken too much of this medication.

Kapvay FDA Approval:
September 29, 2009

Kapvay Recall/Black Box Warning Information:
Kapvay does not carry any black box warnings.

---------------------------------------------------------------
 详细处方信息以本药内容附件PDF文件（201132721470519.pdf）的“原文Priscribing Information”为准
---------------------------------------------------------------