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  药店国别: 美国药房
产地国家: 美国
所属类别: 妇科药物->子宫出血
处方药:处方药
包装规格: 0.2毫克/毫升/安醅 20安醅/盒
计价单位:
  点击放大  
生产厂家中文参考译名:
诺华
生产厂家英文名:
Novartis
该药品相关信息网址1:
www.drugs.com/pro/methergine.html
该药品相关信息网址2:
www.rxlist.com/methergine-drug.htm
该药品相关信息网址3:
http://www.pdrhealth.com/drugs/methergine
原产地英文商品名:
METHERGINE 0.2MG/ML/AMPUL 20AMPULS/BOX
原产地英文药品名:
METHYLERGONOVINE MALEATE
中文参考商品译名:
METHERGINE 0.2毫克/毫升/安醅 20安醅/盒
中文参考药品译名:
马来酸甲基麦角新碱
原产地国家批准上市年份:
1946/11/19
英文适应病症1:
Uterine bleeding
临床试验期:
完成
中文适应病症参考翻译1:
子宫出血
药品信息:

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 详细处方信息以本药内容附件PDF文件(20098402105624.pdf)的“原文Priscribing Information”为准
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部分中文甲基麦角新碱处方资料(仅供参考)

分类名称
一级分类:妇产科用药 二级分类:子宫收缩及引产药物
 
药品英文名
Methylergometrine
 
药品别名
甲基麦角新碱、马来酸甲麦角新碱、美飞占、Eegobacin、Elamidon、Methergin、Methylergobasine、Methylergobrevine、Methylergometrine Maleate、Methylergometrinum、Methylergonovine、Methylergonovine Maleate
 
药物剂型
片剂:0.2mg。注射液:1ml:0.2mg。
 
药理作用
本药为麦角新碱的半合成衍生物,是作用强而持久的子宫收缩药。本药能直接作用于子宫平滑肌,对子宫体和子宫颈均有兴奋作用。其作用的强弱与子宫生理状态和用药剂量有关。妊娠子宫对本药较未孕子宫敏感,临产或产后子宫更为敏感。本药大剂量时可使子宫肌强直性收缩,从而使肌层内血管受到机械性压迫而止血。本药对周围血管的效应较麦角胺类生物碱弱,血压极少升高。
 
药动学
本药口服或肌内注射后吸收迅速而完全。口服后6~15min起效,肌内注射后2~5min起效,作用持续约3h。静脉注射几乎立即起效,作用持续约45min,节律性收缩可持续达3h。药物经肝脏代谢失效,仅少量(低于5%)经肾随尿排出,半衰期为0.5~2h。
 
适应证
用于预防和治疗产后或流产后子宫收缩无力或缩复不良所致的子宫出血。
 
禁忌证
1.胎儿及胎盘娩出前(以免发生子宫破裂、胎儿宫内窒息死亡及胎盘嵌留官腔内)。2.妊娠期间。3.对本药过敏(国外资料)。 

注意事项
1.交叉过敏:对其他麦角制剂过敏者,也可能对本药过敏。2.慎用:(1)冠心病(血管痉挛时可造成心绞痛或心肌梗死)。(2)肝、肾功能损害。(3)低血钙。(4)闭塞性周围血管病。(5)高血压。(6)存在感染时(感染可增强本药的敏感性)。3.药物对妊娠的影响:妊娠期间禁用本药。美国药品和食品管理局(FDA)对本药的妊娠安全性分级为C级。4.药物对哺乳的影响:本药可随乳汁分泌,使婴儿出现麦角样毒性反应,同时还可能抑制泌乳,哺乳妇女应权衡利弊后用药。本药一次剂量不应超过0.5mg,且不宜以静脉注射作为常规使用。6.本药用量不得过大,用药时间不得过长,超量时可发生麦角样中毒及麦角性坏疽。7.对低钙血症者,本药的效应减弱,应谨慎静脉注射钙盐,以恢复宫缩。8.本药不得与其他麦角碱、血管收缩药(包括局麻药液中含有者)和洋地黄类药同用。9.用药后若出现突发性严重高血压,使用氯丙嗪可得到改善甚至消失。10. 贮法:密闭避光,于2~10℃保存。
 
不良反应
由于产后或流产后子宫出血的用药时间较短,本药的某些不良反应较其他麦角生物碱少见。1.静脉给药时,可出现头痛、头晕、耳鸣、恶心、呕吐、腹痛、胸痛、呼吸困难、心悸、心动过缓以及突发性严重高血压。2.如使用不当,可能发生麦角样中毒,表现为持久腹泻、手和下肢皮肤苍白发冷、心搏弱、持续呕吐、惊厥等。
 
用法用量
成人常规剂量:口服给药:一次0.2~0.4mg,一日2~4次,直到宫缩无力纠正和流血明显减少。一般48h为一疗程。肌内注射:一次0.2mg,必要时每2~4小时1次,最多5次。静脉注射:用于子宫大出血时,剂量同肌内注射,稀释后缓慢注射,推注时间至少1min。
 
药物相应作用
1.与升压药合用,有出现严重高血压,甚至脑血管破裂的危险。2.烟碱可使本药的血管收缩作用加剧,故用药期间不得吸烟。

Methergine
Generic Name: Methylergonovine

What is Methergine?
Methergine is a medication known as an ergot alkaloid that is used to help prevent and control bleeding in women after delivery of a baby. Methergine can also be used for other conditions, as determined by your doctor.

What is the most important information I should know about Methergine?
Methergine should be given cautiously to those with sepsis (infection of the blood), obliterative vascular disease (disease of the blood vessels), and liver or kidney disease.

Methergine oral tablets should not be taken for more than 1 week following childbirth.

Who should not take Methergine?
You should not take Methergine if you have high blood pressure, are pregnant, are allergic to Methergine or any of its ingredients, or have had toxemia (a condition in pregnancy characterized by high blood pressure, leakage of protein in the urine, and swelling of the hands, feet, and face).

What should I tell my doctor before I take the first dose of Methergine?
Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Methergine. Also, talk to your doctor about your complete medical history, especially if you are pregnant or nursing, have high blood pressure, kidney disease, liver disease, or infection of the blood.

What is the usual dosage?
The information below is based on the dosage guidelines your doctor uses. Depending on your condition and medical history, your doctor may prescribe a different regimen. Do not change the dosage or stop taking your medication without your doctor's approval.

Methergine may be given as an injection or may be taken orally. If given as an injection, your doctor will prescribe and administer the appropriate dosage for you.

Adults: For the oral tablet, the recommended dose is 1 tablet (0.2 milligrams) by mouth 3-4 times a day after childbirth for up to a maximum of 1 week.

How should I take Methergine?
Methergine oral tablets should be taken by mouth 3-4 times a day, or as directed by your doctor.

What should I avoid while taking Methergine?
Grapefruit and grapefruit juice may interact with Methergine. Discuss the use of grapefruit products with your doctor.

What are possible food and drug interactions associated with Methergine?
If Methergine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Methergine with the following: azole antifungals (e.g. itraconazole, ketoconazole, voriconazole), ergot alkaloids (e.g. dihydroergotamine, ergotamine), fluconazole, fluoxetine, grapefruit juice, HIV protease or reverse transcriptase inhibitors (e.g. delavirdine, indinavir, nelfinavir), macrolide antibiotics (e.g. erythromycin, clarithromycin, troleandomycin), nefazodone, and saquinavir.

This listing does not include all of the possible drug interactions that may occur. Always check with your doctor before combining Methergine with any other drugs, herbs, or supplements.

What are the possible side effects of Methergine?
Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking this drug.

Side effects may include: high blood pressure with or without headache and/or seizures, low blood pressure, nausea, vomiting

Can I receive Methergine if I am pregnant or breastfeeding?
Methergine should not be used if you are pregnant. Talk with your doctor if you are nursing, pregnant, or plan on becoming pregnant.

What should I do if I miss a dose of Methergine?
If you miss a dose of Methergine, take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the one you missed and return to your regular dosing schedule. Do not take two doses at once.

How should I store Methergine?
Store Methergine tablets at room temperature.

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 详细处方信息以本药内容附件PDF文件(20098402105624.pdf)的“原文Priscribing Information”为准
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更新日期: 2012-5-17
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