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 详细处方信息以本药内容附件PDF文件（201121720312225.pdf）的“原文Priscribing Information”为准
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部分中文夫西地酸处方资料（仅供参考）

【商品名】立思丁

【中文名称】夫西地酸

【产品英文名称】Fusidic Acid

【生产企业】Leo Pharmaceutical Product Ltd.A/S

【功效主治】夫西地酸乳膏适用于各种细菌性皮肤感染，主要用于革兰氏阳性球菌引起的皮肤感染。如脓疱病，疖肿，毛囊炎，甲沟炎，须疮，汗腺炎，红癣，寻常痤疮，创伤合并感染，湿疹合并感染，溃疡合并感染等

【化学成分】夫西地酸。化学名称为：反-16α-羧基-3β,11β-二羟基-4β,8β,14α-三甲基-18-去甲基-5β,10α-胆甾-(17Z)-17(20)，24-二烯-21-酸半水合物

【药理作用】夫西地酸是窄谱、高效的类甾体结构抗生素，其抗菌机制是通过抑制核糖体的易位来干扰延长因子G，阻止细菌蛋白的合成，这种独特的作用机制避免了与其他抗菌药物的交叉耐受性夫西地酸对与皮肤感染有关的各种革兰氏阳性球菌尤其对葡萄球菌高度敏感，对耐药金黄色葡萄球菌也有效，对某些革兰氏阴性菌也有一定的抗菌作用。与其它抗生素无交叉耐药性

【药物相互作用】局部用药尚无药物相互作用的相关报道

【不良反应】局部应用本品一般无副反应，偶尔会有轻微的刺激感，对腿部深度溃疡的治疗会伴有疼痛，但通常无需停药。罕见过敏反应。

【禁忌症】对药品过敏者。

【用法用量】本品应局部涂于患处，并缓和地摩擦；必要时可用多孔绷带包扎患处。每日二至三次，七天为一疗程，必要时可重复一个疗程

【贮藏方法】15~25℃密闭保存，置于儿童不易触及之处。

【注意事项】夫西地酸对眼结膜有刺激作用，尽量避免在眼睛周围使用；当治疗严重皮肤感染或顽固性皮肤疾病时，应辅助进行抗生素的全身用药；若发生严重刺激作用或出现过敏反应时，应停止用药并改用其它适当的药物治疗

Fucidin H cream
Main use：Infected eczema

Active ingredient：Hydrocortisone acetate, fusidic acid

Manufacturer：Leo
   
How does it work?
Fucidin H cream contains two active ingredients, hydrocortisone acetate and fusidic acid.

Hydrocortisone acetate is a type of medicine known as a corticosteroid (or steroid). Corticosteroids are hormones that are produced naturally by the adrenal glands, and have many important functions, including control of inflammatory responses.

Hydrocortisone is the same as the natural corticosteroid, cortisol, and is used to decrease inflammation in the skin. When applied to the skin it is absorbed into the skin cells. Here it works by preventing the release of certain chemicals from the cells. These chemicals are important in the immune system, and are released as a result of allergy or irritation. They cause blood vessels to widen, resulting in the affected area of skin becoming red, swollen, itchy and painful, as is seen in dermatitis or eczema. By decreasing the release of these chemicals in the skin, hydrocortisone reduces inflammation and relieves itch.

There is a range of potencies of corticosteroids applied to the skin. Hydrocortisone is classed as a mild corticosteroid. It is used to treat a wide variety of inflammatory skin disorders such as eczema and dermatitis.

Fusidic acid is an antibiotic medicine. It works by entering bacterial cells and interfering with the production of proteins that the bacteria need to divide and multiply. It doesn’t directly kill the bacteria, but leaves them unable to increase in numbers. The existing bacteria eventually die or are destroyed by the immune system. Fusidic acid is included in this preparation to treat the bacteria that sometimes infect inflammatory skin diseases.

The combination of hydrocortisone and fusidic acid is used to treat eczema and dermatitis that are infected with bacteria. The hydrocortisone reduces the inflammation in the skin while the fusidic acid treats the infection.

What is it used for?
Eczema or dermatitis infected with bacteria sensitive to fusidic acid.

Warning!
Fucidin H cream is for external use on the skin only.
This medicine should be applied thinly and evenly to the affected area(s) as directed by your doctor.
Wash your hands thoroughly after applying this medicine, unless the hands are the area being treated.
Avoid contact of this medicine with open wounds and with the eyes and the moist membranes lining the inside of certain parts of the body, eg mouth, nasal passages (mucous membranes). Rinse with cold water if accidental contact occurs.
If your doctor has advised you to use dressings with this medicine, the skin should be cleansed before reapplying the cream under a fresh dressing.
If corticosteroids are used long-term, on large areas of skin, raw skin, skin folds, or under airtight dressings (including nappies) they are absorbed into the body more. This increases the risk of local side effects such as skin thinning, and those on other parts of the body, such as a decrease in the production of natural hormones by the adrenal glands. For this reason, continuous, long-term use of this medicine should be avoided wherever possible, particularly in children and on large areas of skin. You should only use airtight dressings over the affected area if instructed by your doctor.
A single course of treatment with this medicine should not normally exceed two weeks. Prolonged or recurrent application of this medicine may increase the risk of hypersensitivity (allergic) reactions and the development of resistance to the antibiotic.
Consult your doctor if any infection spreads, or if after seven days of treatment with this medicine there is little or no improvement in your symptoms, as you may need to stop using this medicine or take a course of antibiotics by mouth.

Use with caution in
Children.

Not to be used in
Bacterial skin infection that is not secondary to the eczema or dermatitis, (primary infection, eg impetigo).
Fungal skin infections, eg athlete's foot, ringworm, candida skin infections.
Viral skin infections such as chickenpox or herpes simplex.
Tuberculosis affecting the skin.
Skin rashes caused by syphilis.
Acne rosacea.
Acne vulgaris.
Inflammatory rash around the mouth (perioral dermatitis).
Skin ulcers.
Itchy skin around the genitals or anus.
Areas of skin that are very thin and fragile or have broken veins.

This medicine should not be used if you are allergic to one of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine should not be used during pregnancy unless considered essential by your doctor. If it is prescribed by your doctor it should not be used on large areas of skin, underneath airtight dressings, or for prolonged periods of time. Consult your doctor for further information.
This medicine should not be used during breastfeeding unless considered essential by your doctor. If it is prescribed by your doctor it should not be used on large areas of skin, underneath airtight dressings or for prolonged periods of time. If it is applied to the breasts it should be washed off carefully before breastfeeding and then reapplied afterwards.

Label warnings
This medication is to be spread thinly and sparingly on the skin.

Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Skin irritation, eg itching, burning, stinging
Rash.
Worsening of eczema.
Skin thinning, thread veins or stretch marks (prolonged use only).
Inflammation of hair follicles (folliculitis).
Decreased skin pigmentation at application area.
Increased hair growth at application area.
Contact dermatitis.

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?
This medicine is not known to affect other medicines. However, as with all medicines, it is important to tell your doctor or pharmacist what medicines you are already using, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before using any new medicines while using this one, to ensure that the combination is safe.

Other medicines containing the same active ingredients
There are currently no other medicines available in the UK that contain both hydrocortisone and fusidic acid as the active ingredients.

However, both medicines are available separately.

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 详细处方信息以本药内容附件PDF文件（201121720312225.pdf）的“原文Priscribing Information”为准
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2011-2-18更新